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Scaling rules for diffusive drug delivery in tumor and normal tissues

Delivery of blood-borne molecules and nanoparticles from the vasculature to cells in the tissue differs dramatically between tumor and normal tissues due to differences in their vascular architectures. Here we show that two simple measures of vascular geometry—δ(max) and λ—readily obtained from vasc...

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Detalhes bibliográficos
Main Authors: Baish, James W., Stylianopoulos, Triantafyllos, Lanning, Ryan M., Kamoun, Walid S., Fukumura, Dai, Munn, Lance L., Jain, Rakesh K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033252/
https://ncbi.nlm.nih.gov/pubmed/21224417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018154108
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