Rho GTPase Cdc42 Is a Direct Interacting Partner of Adenomatous Polyposis Coli Protein and Can Alter Its Cellular Localization

Adenomatous Polyposis Coli (APC) is a tumor suppressor gene product involved in colon cancer. APC is a large multidomain molecule of 2843 amino acid residues and connects cell-cell adhesion, the F-actin/microtubule cytoskeleton and the nucleus. Here we show that Cdc42 interacts directly with the fir...

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Détails bibliographiques
Auteurs principaux: Sudhaharan, Thankiah, Goh, Wah Ing, Sem, Kai Ping, Lim, Kim Buay, Bu, Wenyu, Ahmed, Sohail
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032772/
https://ncbi.nlm.nih.gov/pubmed/21311754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016603
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