Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

Caloric restriction and autophagy-inducing pharmacological agents can prolong lifespan in model organisms including mice, flies, and nematodes. In this study, we show that transgenic expression of Sirtuin-1 induces autophagy in human cells in vitro and in Caenorhabditis elegans in vivo. The knockdow...

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Autors principals: Morselli, E, Maiuri, M C, Markaki, M, Megalou, E, Pasparaki, A, Palikaras, K, Criollo, A, Galluzzi, L, Malik, S A, Vitale, I, Michaud, M, Madeo, F, Tavernarakis, N, Kroemer, G
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032517/
https://ncbi.nlm.nih.gov/pubmed/21364612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2009.8
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