Construction and characterization of attenuated delta aroA delta virG Shigella flexneri 2a strain CVD 1203, a prototype live oral vaccine.

We engineered an oral Shigella vaccine prototype that can invade intestinal epithelial cells but cannot undergo extensive intracellular replication or extend to adjacent epithelial cells. Strain CVD 1203, derived from wild-type Shigella flexneri 2a by introducing deletions in chromosomal aroA and in...

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Εκδόθηκε σε:	Infect Immun
Κύριοι συγγραφείς:	Noriega, F R, Wang, J Y, Losonsky, G, Maneval, D R, Hone, D M, Levine, M M
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Microbiology (ASM) 1994
Θέματα:	Research Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303242/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7927802/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.62.11.5168-5172.1994
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