Construction and characterization of attenuated delta aroA delta virG Shigella flexneri 2a strain CVD 1203, a prototype live oral vaccine.

We engineered an oral Shigella vaccine prototype that can invade intestinal epithelial cells but cannot undergo extensive intracellular replication or extend to adjacent epithelial cells. Strain CVD 1203, derived from wild-type Shigella flexneri 2a by introducing deletions in chromosomal aroA and in...

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發表在:	Infect Immun
Principais autores:	Noriega, F R, Wang, J Y, Losonsky, G, Maneval, D R, Hone, D M, Levine, M M
格式:	Artigo
語言:	Inglês
出版:	American Society for Microbiology (ASM) 1994
主題:	Research Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303242/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7927802/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.62.11.5168-5172.1994
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