Construction and characterization of attenuated delta aroA delta virG Shigella flexneri 2a strain CVD 1203, a prototype live oral vaccine.

We engineered an oral Shigella vaccine prototype that can invade intestinal epithelial cells but cannot undergo extensive intracellular replication or extend to adjacent epithelial cells. Strain CVD 1203, derived from wild-type Shigella flexneri 2a by introducing deletions in chromosomal aroA and in...

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Dades bibliogràfiques

Publicat a:	Infect Immun
Autors principals:	Noriega, F R, Wang, J Y, Losonsky, G, Maneval, D R, Hone, D M, Levine, M M
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 1994
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303242/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7927802/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.62.11.5168-5172.1994
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