Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK

Direct pharmacological targeting of the anti-apoptotic B-cell lymphoma-2 (BCL-2) family is an attractive therapeutic strategy for treating cancer. Obatoclax is a pan-BCL-2 family inhibitor currently in clinical development. Here we show that, although obatoclax can induce mitochondrial apoptosis dep...

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Main Authors: McCoy, F, Hurwitz, J, McTavish, N, Paul, I, Barnes, C, O'Hagan, B, Odrzywol, K, Murray, J, Longley, D, McKerr, G, Fennell, D A
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
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Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032298/
https://ncbi.nlm.nih.gov/pubmed/21368880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2010.86
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