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Somatic cell reprogramming and transitions between pluripotent states: facts, hypotheses, unresolved issues

Direct reprogramming of somatic cells to induced pluripotent stem cells by ectopic expression of defined transcription factors has raised fundamental questions regarding the epigenetic stability of the differentiated cell state. In addition, evidence has accumulated that distinct states of pluripote...

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Detalhes bibliográficos
Main Authors: Hanna, Jacob H., Saha, Krishanu, Jaenisch, Rudolf
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032267/
https://ncbi.nlm.nih.gov/pubmed/21074044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.10.008
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