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Somatic cell reprogramming and transitions between pluripotent states: facts, hypotheses, unresolved issues

Direct reprogramming of somatic cells to induced pluripotent stem cells by ectopic expression of defined transcription factors has raised fundamental questions regarding the epigenetic stability of the differentiated cell state. In addition, evidence has accumulated that distinct states of pluripote...

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Autors principals: Hanna, Jacob H., Saha, Krishanu, Jaenisch, Rudolf
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032267/
https://ncbi.nlm.nih.gov/pubmed/21074044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.10.008
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