Principal-Component Analysis for Assessment of Population Stratification in Mitochondrial Medical Genetics

Although inherited mitochondrial genetic variation can cause human disease, no validated methods exist for control of confounding due to mitochondrial population stratification (PS). We sought to identify a reliable method for PS assessment in mitochondrial medical genetics. We analyzed mitochondria...

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Hlavní autoři: Biffi, Alessandro, Anderson, Christopher D., Nalls, Michael A., Rahman, Rosanna, Sonni, Akshata, Cortellini, Lynelle, Rost, Natalia S., Matarin, Mar, Hernandez, Dena G., Plourde, Anna, de Bakker, Paul I.W., Ross, Owen A., Greenberg, Steven M., Furie, Karen L., Meschia, James F., Singleton, Andrew B., Saxena, Richa, Rosand, Jonathan
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032075/
https://ncbi.nlm.nih.gov/pubmed/20537299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2010.05.005
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