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Pooled Association Tests for Rare Variants in Exon-Resequencing Studies
Deep sequencing will soon generate comprehensive sequence information in large disease samples. Although the power to detect association with an individual rare variant is limited, pooling variants by gene or pathway into a composite test provides an alternative strategy for identifying susceptibili...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3032073/ https://ncbi.nlm.nih.gov/pubmed/20471002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2010.04.005 |
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