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On optimal pooling designs to identify rare variants through massive resequencing
The advent of next-generation sequencing technologies has facilitated the detection of rare variants. Despite the significant cost reduction, sequencing cost is still high for large-scale studies. In this article, we examine DNA pooling as a cost-effective strategy for rare variant detection. We con...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Wiley Subscription Services, Inc., A Wiley Company
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3176340/ https://ncbi.nlm.nih.gov/pubmed/21254222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.20561 |
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