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On optimal pooling designs to identify rare variants through massive resequencing

The advent of next-generation sequencing technologies has facilitated the detection of rare variants. Despite the significant cost reduction, sequencing cost is still high for large-scale studies. In this article, we examine DNA pooling as a cost-effective strategy for rare variant detection. We con...

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Detalhes bibliográficos
Main Authors: Lee, Joon Sang, Choi, Murim, Yan, Xiting, Lifton, Richard P, Zhao, Hongyu
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176340/
https://ncbi.nlm.nih.gov/pubmed/21254222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.20561
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