Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

More than a thousand disease susceptibility loci have been identified via genome-wide association studies (GWAS) of common variants; however, the specific genes and full allelic spectrum of causal variants underlying these findings generally remain to be defined. We utilize pooled next-generation se...

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Detalhes bibliográficos
Main Authors: Rivas, Manuel A., Beaudoin, Melissa, Gardet, Agnes, Stevens, Christine, Sharma, Yashoda, Zhang, Clarence K., Boucher, Gabrielle, Ripke, Stephan, Ellinghaus, David, Burtt, Noel, Fennell, Tim, Kirby, Andrew, Latiano, Anna, Goyette, Philippe, Green, Todd, Halfvarson, Jonas, Haritunians, Talin, Korn, Joshua M., Kuruvilla, Finny, Lagacé, Caroline, Neale, Benjamin, Lo, Ken Sin, Schumm, Phil, Törkvist, Leif, Dubinsky, Marla, Brant, Steven R., Silverberg, Mark, Duerr, Richard H., Altshuler, David, Gabriel, Stacey, Lettre, Guillaume, Franke, Andre, D’Amato, Mauro, McGovern, Dermot P.B., Cho, Judy H., Rioux, John D., Xavier, Ramnik J., Daly, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378381/
https://ncbi.nlm.nih.gov/pubmed/21983784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.952
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