Skeletal Muscle 11beta-HSD1 Controls Glucocorticoid-Induced Proteolysis and Expression of E3 Ubiquitin Ligases Atrogin-1 and MuRF-1

Recent studies demonstrated expression and activity of the intracellular cortisone-cortisol shuttle 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in skeletal muscle and inhibition of 11beta-HSD1 in muscle cells improved insulin sensitivity. Glucocorticoids induce muscle atrophy via increa...

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Bibliografiske detaljer
Main Authors: Biedasek, Katrin, Andres, Janin, Mai, Knut, Adams, Stephanie, Spuler, Simone, Fielitz, Jens, Spranger, Joachim
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031623/
https://ncbi.nlm.nih.gov/pubmed/21304964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016674
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