Peripheral Delivery of a CNS Targeted, Metalo-Protease Reduces Aβ Toxicity in a Mouse Model of Alzheimer's Disease

Alzheimer's disease (AD), an incurable, progressive neurodegenerative disorder, is the most common form of dementia. Therapeutic options have been elusive due to the inability to deliver proteins across the blood-brain barrier (BBB). In order to improve the therapeutic potential for AD, we util...

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Main Authors: Spencer, Brian, Marr, Robert A., Gindi, Ryan, Potkar, Rewati, Michael, Sarah, Adame, Anthony, Rockenstein, Edward, Verma, Inder M., Masliah, Eliezer
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031588/
https://ncbi.nlm.nih.gov/pubmed/21304989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016575
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