Peripheral Delivery of a CNS Targeted, Metalo-Protease Reduces Aβ Toxicity in a Mouse Model of Alzheimer's Disease

Alzheimer's disease (AD), an incurable, progressive neurodegenerative disorder, is the most common form of dementia. Therapeutic options have been elusive due to the inability to deliver proteins across the blood-brain barrier (BBB). In order to improve the therapeutic potential for AD, we util...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Spencer, Brian, Marr, Robert A., Gindi, Ryan, Potkar, Rewati, Michael, Sarah, Adame, Anthony, Rockenstein, Edward, Verma, Inder M., Masliah, Eliezer
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2011
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031588/
https://ncbi.nlm.nih.gov/pubmed/21304989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016575
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