Apolipoprotein E: Isoform Specific Differences in Tertiary Structure and Interaction with Amyloid-β in Human Alzheimer Brain

We applied a novel application of FLIM-FRET to in situ measurement and quantification of protein interactions to explore isoform specific differences in Aβ-ApoE interaction and ApoE tertiary conformation in senile plaques in human Alzheimer brain. ApoE3 interacts more closely with Aβ than ApoE4, but...

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Autors principals: Jones, Phillip B., Adams, Kenneth W., Rozkalne, Anete, Spires-Jones, Tara L., Hshieh, Tammy T., Hashimoto, Tadafumi, von Armin, Christine A. F., Mielke, Mathew, Bacskai, Brian J., Hyman, Bradley T.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031506/
https://ncbi.nlm.nih.gov/pubmed/21297948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014586
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