DNA Methylation Changes Following 5-azacitidine Treatment in Patients with Myelodysplastic Syndrome

DNA methyltransferase inhibitor, 5-azacitidine (AC) is effective in myelodysplastic syndromes (MDS) and can induce re-expression in cancer. We analyzed the methylation of 25 tumor suppressor genes in AC-treated MDS. Hypermethylation of CDKN2B, FHIT, ESR1, and IGSF4 gene was detected in 9/44 patients...

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Hlavní autoři: Tran, Huong Thi Thanh, Kim, Hee Nam, Lee, Il-Kwon, Kim, Yeo-Kyeoung, Ahn, Jae-Sook, Yang, Deok-Hwan, Lee, Je-Jung, Kim, Hyeoung-Joon
Médium: Artigo
Jazyk:Inglês
Vydáno: The Korean Academy of Medical Sciences 2011
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031004/
https://ncbi.nlm.nih.gov/pubmed/21286011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3346/jkms.2011.26.2.207
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