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DNA Methylation Changes Following 5-azacitidine Treatment in Patients with Myelodysplastic Syndrome
DNA methyltransferase inhibitor, 5-azacitidine (AC) is effective in myelodysplastic syndromes (MDS) and can induce re-expression in cancer. We analyzed the methylation of 25 tumor suppressor genes in AC-treated MDS. Hypermethylation of CDKN2B, FHIT, ESR1, and IGSF4 gene was detected in 9/44 patients...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Korean Academy of Medical Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3031004/ https://ncbi.nlm.nih.gov/pubmed/21286011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3346/jkms.2011.26.2.207 |
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