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Aberrant Promoter CpG Methylation Is a Mechanism for Impaired PHD3 Expression in a Diverse Set of Malignant Cells

BACKGROUND: The prolyl-hydroxylase domain family of enzymes (PHD1-3) plays an important role in the cellular response to hypoxia by negatively regulating HIF-α proteins. Disruption of this process can lead to up-regulation of factors that promote tumorigenesis. We observed decreased basal expression...

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Autores principales: Place, Trenton L., Fitzgerald, Matthew P., Venkataraman, Sujatha, Vorrink, Sabine U., Case, Adam J., Teoh, Melissa L. T., Domann, Frederick E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030558/
https://ncbi.nlm.nih.gov/pubmed/21297970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014617
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