Targeting Toll-like receptor 7/8 enhances uptake of apoptotic leukemic cells by monocyte-derived dendritic cells but interferes with subsequent cytokine-induced maturation

Therapeutic vaccination with dendritic cells (DC) is an emerging investigational therapy for eradication of minimal residual disease in acute myeloid leukemia. Various strategies are being explored in manufacturing DC vaccines ex vivo, e.g., monocyte-derived DC (MoDC) loaded with leukemia-associated...

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Bibliographische Detailangaben
Hauptverfasser: van den Ancker, Willemijn, van Luijn, Marvin M., Ruben, Jurjen M., Westers, Theresia M., Bontkes, Hetty J., Ossenkoppele, Gert J., de Gruijl, Tanja D., van de Loosdrecht, Arjan A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer-Verlag 2010
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029806/
https://ncbi.nlm.nih.gov/pubmed/20859626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-010-0917-y
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