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Ligand binding to protein-binding pockets with wet and dry regions

Biological processes often depend on protein–ligand binding events, yet accurate calculation of the associated energetics remains as a significant challenge of central importance to structure-based drug design. Recently, we have proposed that the displacement of unfavorable waters by the ligand, rep...

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Detaylı Bibliyografya
Asıl Yazarlar: Wang, Lingle, Berne, B. J., Friesner, R. A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2011
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029693/
https://ncbi.nlm.nih.gov/pubmed/21205906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016793108
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