Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas

The receptor tyrosine kinase MET is frequently amplified in human tumors, resulting in high cell surface densities and constitutive activation even in the absence of growth factor stimulation by its endogenous ligand, hepatocyte growth factor (HGF). We sought to identify mechanisms of signaling cros...

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Hlavní autoři: Looyenga, Brendan D., Furge, Kyle A., Dykema, Karl J., Koeman, Julie, Swiatek, Pamela J., Giordano, Thomas J., West, Andrew B., Resau, James H., Teh, Bin T., MacKeigan, Jeffrey P.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2011
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029686/
https://ncbi.nlm.nih.gov/pubmed/21220347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012500108
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