Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas

The receptor tyrosine kinase MET is frequently amplified in human tumors, resulting in high cell surface densities and constitutive activation even in the absence of growth factor stimulation by its endogenous ligand, hepatocyte growth factor (HGF). We sought to identify mechanisms of signaling cros...

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Main Authors: Looyenga, Brendan D., Furge, Kyle A., Dykema, Karl J., Koeman, Julie, Swiatek, Pamela J., Giordano, Thomas J., West, Andrew B., Resau, James H., Teh, Bin T., MacKeigan, Jeffrey P.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029686/
https://ncbi.nlm.nih.gov/pubmed/21220347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012500108
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