Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas

The receptor tyrosine kinase MET is frequently amplified in human tumors, resulting in high cell surface densities and constitutive activation even in the absence of growth factor stimulation by its endogenous ligand, hepatocyte growth factor (HGF). We sought to identify mechanisms of signaling cros...

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Главные авторы: Looyenga, Brendan D., Furge, Kyle A., Dykema, Karl J., Koeman, Julie, Swiatek, Pamela J., Giordano, Thomas J., West, Andrew B., Resau, James H., Teh, Bin T., MacKeigan, Jeffrey P.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2011
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029686/
https://ncbi.nlm.nih.gov/pubmed/21220347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012500108
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