Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas

The receptor tyrosine kinase MET is frequently amplified in human tumors, resulting in high cell surface densities and constitutive activation even in the absence of growth factor stimulation by its endogenous ligand, hepatocyte growth factor (HGF). We sought to identify mechanisms of signaling cros...

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Bibliographic Details
Main Authors:	Looyenga, Brendan D., Furge, Kyle A., Dykema, Karl J., Koeman, Julie, Swiatek, Pamela J., Giordano, Thomas J., West, Andrew B., Resau, James H., Teh, Bin T., MacKeigan, Jeffrey P.
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 2011
Subjects:	Biological Sciences
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3029686/ https://ncbi.nlm.nih.gov/pubmed/21220347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012500108
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Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas

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