RNF12 Activates Xist and Is Essential for X Chromosome Inactivation

In somatic cells of female placental mammals, one of the two X chromosomes is transcriptionally silenced to accomplish an equal dose of X-encoded gene products in males and females. Initiation of random X chromosome inactivation (XCI) is thought to be regulated by X-encoded activators and autosomall...

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Main Authors: Barakat, Tahsin Stefan, Gunhanlar, Nilhan, Gontan Pardo, Cristina, Achame, Eskeatnaf Mulugeta, Ghazvini, Mehrnaz, Boers, Ruben, Kenter, Annegien, Rentmeester, Eveline, Grootegoed, J. Anton, Gribnau, Joost
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029249/
https://ncbi.nlm.nih.gov/pubmed/21298085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002001
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