The Probability to Initiate X Chromosome Inactivation Is Determined by the X to Autosomal Ratio and X Chromosome Specific Allelic Properties

BACKGROUND: In female mammalian cells, random X chromosome inactivation (XCI) equalizes the dosage of X-encoded gene products to that in male cells. XCI is a stochastic process, in which each X chromosome has a probability to be inactivated. To obtain more insight in the factors setting up this prob...

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Main Authors: Monkhorst, Kim, de Hoon, Bas, Jonkers, Iris, Mulugeta Achame, Eskeatnaf, Monkhorst, Wouter, Hoogerbrugge, Jos, Rentmeester, Eveline, Westerhoff, Hans V., Grosveld, Frank, Grootegoed, J. Anton, Gribnau, Joost
格式: Artigo
語言:Inglês
出版: Public Library of Science 2009
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680018/
https://ncbi.nlm.nih.gov/pubmed/19440388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005616
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