Loss of polyubiquitin gene Ubb leads to metabolic and sleep abnormalities in mice

AIMS: Ubiquitin performs essential roles in a myriad of signalling pathways required for cellular function and survival. Recently, we reported that disruption of the stress-inducible ubiquitin-encoding gene Ubb reduces ubiquitin content in the hypothalamus and leads to adult-onset obesity coupled wi...

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Main Authors: Ryu, K.-Y., Fujiki, N., Kazantzis, M., Garza, J. C., Bouley, D. M., Stahl, A., Lu, X.-Y., Nishino, S., Kopito, R. R.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029017/
https://ncbi.nlm.nih.gov/pubmed/20002312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2990.2009.01057.x
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