Structure-Function Analyses Point to a Polynucleotide-Accommodating Groove Essential for APOBEC3A Restriction Activities

Members of the human APOBEC3 family of editing enzymes can inhibit various mobile genetic elements. APOBEC3A (A3A) can block the retrotransposon LINE-1 and the parvovirus adeno-associated virus type 2 (AAV-2) but does not inhibit retroviruses. In contrast, APOBEC3G (A3G) can block retroviruses but h...

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Detalhes bibliográficos
Main Authors: Bulliard, Yannick, Narvaiza, Iñigo, Bertero, Alessandro, Peddi, Shyam, Röhrig, Ute F., Ortiz, Millán, Zoete, Vincent, Castro-Díaz, Nataly, Turelli, Priscilla, Telenti, Amalio, Michielin, Olivier, Weitzman, Matthew D., Trono, Didier
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Genetic Diversity and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028873/
https://ncbi.nlm.nih.gov/pubmed/21123384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01651-10
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