APOBEC3A can activate the DNA damage response and cause cell-cycle arrest

Human apolipoprotein-B mRNA-editing catalytic polypeptide-like 3 (APOBEC3) proteins constitute a family of cytidine deaminases that mediate restriction of retroviruses, endogenous retro-elements and DNA viruses. It is well established that these enzymes are potent mutators of viral DNA, but it is un...

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Autors principals: Landry, Sébastien, Narvaiza, Iñigo, Linfesty, Daniel C, Weitzman, Matthew D
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
Matèries:
Scientific Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090015/
https://ncbi.nlm.nih.gov/pubmed/21460793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.46
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