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Receptor Binding Profiles of Avian Influenza Virus Hemagglutinin Subtypes on Human Cells as a Predictor of Pandemic Potential

The host adaptation of influenza virus is partly dependent on the sialic acid (SA) isoform bound by the viral hemagglutinin (HA). Avian influenza viruses preferentially bind the α-2,3 SA and human influenza viruses the α-2,6 isoform. Each isoform is predominantly associated with different surface ep...

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Hlavní autoři: Shelton, Holly, Ayora-Talavera, Guadalupe, Ren, Junyuan, Loureiro, Silvia, Pickles, Raymond J., Barclay, Wendy S., Jones, Ian M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028872/
https://ncbi.nlm.nih.gov/pubmed/21106732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01822-10
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