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Contrasting Effects of Acidic pH on the Extracellular and Intracellular Activities of the Anti-Gram-Positive Fluoroquinolones Moxifloxacin and Delafloxacin against Staphylococcus aureus

In contrast to currently marketed fluoroquinolones, which are zwitterionic, delafloxacin is an investigational fluoroquinolone with an anionic character that is highly active against Gram-positive bacteria. We have examined the effect of acidic pH on its accumulation in Staphylococcus aureus and in...

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Detalhes bibliográficos
Main Authors: Lemaire, Sandrine, Tulkens, Paul M., Van Bambeke, Françoise
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028753/
https://ncbi.nlm.nih.gov/pubmed/21135179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01201-10
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