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Mre11 Nuclease Activity and Ctp1 Regulate Chk1 Activation by Rad3(ATR) and Tel1(ATM) Checkpoint Kinases at Double-Strand Breaks
Rad3, the Schizosaccharomyces pombe ortholog of human ATR and Saccharomyces cerevisiae Mec1, activates the checkpoint kinase Chk1 in response to DNA double-strand breaks (DSBs). Rad3(ATR/Mec1) associates with replication protein A (RPA), which binds single-stranded DNA overhangs formed by DSB resect...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3028622/ https://ncbi.nlm.nih.gov/pubmed/21098122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00994-10 |
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