Nbs1 is a Flexible Arm Binding Ctp1 and Mre11-Rad50 to Coordinate dsDNA Break Processing

The Nijmegen breakage syndrome 1 (Nbs1) subunit of the Mre11-Rad50-Nbs1 (MRN) complex protects genome integrity by coordinating double-strand break (DSB) repair and checkpoint signaling through undefined interactions with ATM, MDC1, and Sae2/Ctp1/CtIP. Here, fission yeast and human Nbs1 structures d...

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Main Authors: Williams, R. Scott, Dodson, Gerald E., Limbo, Oliver, Yamada, Yoshiki, Williams, Jessica S., Guenther, Grant, Classen, Scott, Glover, J.N. Mark, Iwasaki, Hiroshi, Russell, Paul, Tainer, John A.
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762657/
https://ncbi.nlm.nih.gov/pubmed/19804755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.07.033
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