Disruption of Hepatocyte Growth Factor/c-Met Signaling Enhances Pancreatic β-Cell Death and Accelerates the Onset of Diabetes

OBJECTIVE: To determine the role of hepatocyte growth factor (HGF)/c-Met on β-cell survival in diabetogenic conditions in vivo and in response to cytokines in vitro. RESEARCH DESIGN AND METHODS: We generated pancreas-specific c-Met-null (PancMet KO) mice and characterized their response to diabetes...

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Hlavní autoři: Mellado-Gil, Jose, Rosa, Taylor C., Demirci, Cem, Gonzalez-Pertusa, Jose A., Velazquez-Garcia, Silvia, Ernst, Sara, Valle, Shelley, Vasavada, Rupangi C., Stewart, Andrew F., Alonso, Laura C., Garcia-Ocaña, Adolfo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2011
Témata:
Islet Studies
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028352/
https://ncbi.nlm.nih.gov/pubmed/20980460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1305
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