Hepatic Glycogen Supercompensation Activates AMP-Activated Protein Kinase, Impairs Insulin Signaling, and Reduces Glycogen Deposition in the Liver

OBJECTIVE: The objective of this study was to determine how increasing the hepatic glycogen content would affect the liver’s ability to take up and metabolize glucose. RESEARCH DESIGN AND METHODS: During the first 4 h of the study, liver glycogen deposition was stimulated by intraportal fructose inf...

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Detalhes bibliográficos
Main Authors: Winnick, Jason J., An, Zhibo, Ramnanan, Christopher J., Smith, Marta, Irimia, Jose M., Neal, Doss W., Moore, Mary Courtney, Roach, Peter J., Cherrington, Alan D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028338/
https://ncbi.nlm.nih.gov/pubmed/21270252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0592
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