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Endogenous and exogenous glucocorticoids have different roles in modulating endotoxin lethality in D-galactosamine-sensitized mice.

Endotoxin sensitivity and dexamethasone protection have been assessed in mice that were adrenalectomized and also treated with D-galactosamine at the time of endotoxin challenge. Our data establish that adrenalectomy did not detectably alter the magnitude of the increased sensitivity induced by D-ga...

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Udgivet i:Infect Immun
Principais autores: Gonzalez, J C, Johnson, D C, Morrison, D C, Freudenberg, M A, Galanos, C, Silverstein, R
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC302827/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8432617/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.61.3.970-974.1993
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