Reversible valproate hepatotoxicity due to mutations in mitochondrial DNA polymerase γ (POLG1)

We report the case of a 2-year-old boy with seizures who developed hepatic failure shortly after commencing sodium valproate. Unexpectedly, liver function returned to normal on stopping the drug. Sequencing of the mitochondrial polymerase γ gene (POLG1) revealed four heterozygous substitutions, two...

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Detalhes bibliográficos
Main Authors: McFarland, R, Hudson, G, Taylor, R W, Green, S H, Hodges, S, McKiernan, P J, Chinnery, P F, Ramesh, V
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028092/
https://ncbi.nlm.nih.gov/pubmed/21686371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bcr.12.2008.1303
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