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Reversible valproate hepatotoxicity due to mutations in mitochondrial DNA polymerase γ (POLG1)
We report the case of a 2-year-old boy with seizures who developed hepatic failure shortly after commencing sodium valproate. Unexpectedly, liver function returned to normal on stopping the drug. Sequencing of the mitochondrial polymerase γ gene (POLG1) revealed four heterozygous substitutions, two...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BMJ Publishing Group
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3028092/ https://ncbi.nlm.nih.gov/pubmed/21686371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bcr.12.2008.1303 |
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