Development and Characterization of Synthetic Glucopyranosyl Lipid Adjuvant System as a Vaccine Adjuvant

Innate immune responses to vaccine adjuvants based on lipopolysaccharide (LPS), a component of Gram-negative bacterial cell walls, are driven by Toll-like receptor (TLR) 4 and adaptor proteins including MyD88 and TRIF, leading to the production of inflammatory cytokines, type I interferons, and chem...

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Detalhes bibliográficos
Main Authors: Coler, Rhea N., Bertholet, Sylvie, Moutaftsi, Magdalini, Guderian, Jeff A., Windish, Hillarie Plessner, Baldwin, Susan L., Laughlin, Elsa M., Duthie, Malcolm S., Fox, Christopher B., Carter, Darrick, Friede, Martin, Vedvick, Thomas S., Reed, Steven G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3027669/
https://ncbi.nlm.nih.gov/pubmed/21298114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016333
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