Development and Characterization of Synthetic Glucopyranosyl Lipid Adjuvant System as a Vaccine Adjuvant

Innate immune responses to vaccine adjuvants based on lipopolysaccharide (LPS), a component of Gram-negative bacterial cell walls, are driven by Toll-like receptor (TLR) 4 and adaptor proteins including MyD88 and TRIF, leading to the production of inflammatory cytokines, type I interferons, and chem...

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Détails bibliographiques
Auteurs principaux: Coler, Rhea N., Bertholet, Sylvie, Moutaftsi, Magdalini, Guderian, Jeff A., Windish, Hillarie Plessner, Baldwin, Susan L., Laughlin, Elsa M., Duthie, Malcolm S., Fox, Christopher B., Carter, Darrick, Friede, Martin, Vedvick, Thomas S., Reed, Steven G.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3027669/
https://ncbi.nlm.nih.gov/pubmed/21298114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016333
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