Potent in vitro and in vivo anticancer activities of des-methyl, des-amino pateamine A, a synthetic analogue of marine natural product pateamine A

We report here that des-methyl, des-amino pateamine A (DMDA-PatA), a structurally simplified analogue of the marine natural product pateamine A, has potent antiproliferative activity against a wide variety of human cancer cell lines while showing relatively low cytotoxicity against nonproliferating,...

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Autori principali: Kuznetsov, Galina, Xu, Qunli, Rudolph-Owen, Lori, TenDyke, Karen, Liu, Junke, Towle, Murray, Zhao, Nanding, Marsh, Joanne, Agoulnik, Sergei, Twine, Natalie, Parent, Lana, Chen, Zhihong, Shie, Jue-Lon, Jiang, Yimin, Zhang, Huiming, Du, Hong, Boivin, Roch, Wang, Yuan, Romo, Daniel, Littlefield, Bruce A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026899/
https://ncbi.nlm.nih.gov/pubmed/19417157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-1026
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