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Lead exposure increases levels of beta-amyloid in the brain and CSF and inhibits LRP1 expression in APP transgenic mice
Lead (Pb) is an environmental factor suspected of contributing to neurodegenerative diseases such as Alzheimer’s disease (AD). In AD, it has been postulated that increased production and/or decreased metabolism/clearance of beta-amyloid (Aβ) may lead to amyloid plaque deposition as well as a cascade...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3026879/ https://ncbi.nlm.nih.gov/pubmed/21167913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2010.12.017 |
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