Lead exposure increases levels of beta-amyloid in the brain and CSF and inhibits LRP1 expression in APP transgenic mice

Lead (Pb) is an environmental factor suspected of contributing to neurodegenerative diseases such as Alzheimer’s disease (AD). In AD, it has been postulated that increased production and/or decreased metabolism/clearance of beta-amyloid (Aβ) may lead to amyloid plaque deposition as well as a cascade...

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Huvudupphovsmän: Gu, Huiying, Wei, Xing, Monnot, Andrew D., Fontanilla, Christine V., Behl, Mamta, Farlow, Martin R., Zheng, Wei, Du, Yansheng
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026879/
https://ncbi.nlm.nih.gov/pubmed/21167913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2010.12.017
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