Warfarin STEREOCHEMICAL ASPECTS OF ITS METABOLISM AND THE INTERACTION WITH PHENYLBUTAZONE

An examination of the metabolic fate of the R and the S isomers of warfarin revealed that the two isomers were metabolized by different routes. R warfarin was oxidized to 6-hydroxywarfarin and was reduced to the (R,S) warfarin alcohol. In contrast, S warfarin was oxidized to 7-hydroxywarfarin and wa...

詳細記述

書誌詳細

出版年:	J Clin Invest
主要な著者:	Lewis, Richard J., Trager, William F., Chan, Kenneth K., Breckenridge, A., Orme, M., Roland, Malcolm, Schary, William
フォーマット:	Artigo
言語:	Inglês
出版事項:	American Society for Clinical Investigation 1974
主題:	Articles
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC302656/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4830225/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI107711
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