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Warfarin STEREOCHEMICAL ASPECTS OF ITS METABOLISM AND THE INTERACTION WITH PHENYLBUTAZONE

An examination of the metabolic fate of the R and the S isomers of warfarin revealed that the two isomers were metabolized by different routes. R warfarin was oxidized to 6-hydroxywarfarin and was reduced to the (R,S) warfarin alcohol. In contrast, S warfarin was oxidized to 7-hydroxywarfarin and wa...

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Detalhes bibliográficos
Main Authors: Lewis, Richard J., Trager, William F., Chan, Kenneth K., Breckenridge, A., Orme, M., Roland, Malcolm, Schary, William
Formato: Artigo
Idioma:Inglês
Publicado em: 1974
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC302656/
https://ncbi.nlm.nih.gov/pubmed/4830225
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