Warfarin STEREOCHEMICAL ASPECTS OF ITS METABOLISM AND THE INTERACTION WITH PHENYLBUTAZONE

An examination of the metabolic fate of the R and the S isomers of warfarin revealed that the two isomers were metabolized by different routes. R warfarin was oxidized to 6-hydroxywarfarin and was reduced to the (R,S) warfarin alcohol. In contrast, S warfarin was oxidized to 7-hydroxywarfarin and wa...

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Bibliografski detalji

Izdano u:	J Clin Invest
Glavni autori:	Lewis, Richard J., Trager, William F., Chan, Kenneth K., Breckenridge, A., Orme, M., Roland, Malcolm, Schary, William
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Clinical Investigation 1974
Teme:	Articles
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC302656/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4830225/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI107711
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