Crystal Structure of the Pyrazinamidase of Mycobacterium tuberculosis: Insights into Natural and Acquired Resistance to Pyrazinamide

Pyrazinamidase (PncA) activates the first-line antituberculous drug pyrazinamide into pyrazinoic acid. The crystal structure of the Mycobacterium tuberculosis PncA protein has been determined, showing significant differences in the substrate binding cavity when compared to the pyrazinamidases from P...

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Detalhes bibliográficos
Main Authors: Petrella, Stéphanie, Gelus-Ziental, Nathalie, Maudry, Arnaud, Laurans, Caroline, Boudjelloul, Rachid, Sougakoff, Wladimir
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025910/
https://ncbi.nlm.nih.gov/pubmed/21283666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015785
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