Safety, Pharmacokinetics, Pharmacodynamics, and Activity of Navitoclax, a Targeted High Affinity Inhibitor of BCL-2, in Lymphoid Malignancies

BACKGROUND: BCL-2 family proteins play a central role in regulating clonal selection and survival of lymphocytes and are frequently over expressed in lymphomas. Navitoclax (ABT-263) is a targeted high-affinity small molecule that occupies the BH3 binding groove of BCL-2 and BCL-X(L) and inhibits the...

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Main Authors: Wilson, Wyndham H., O’Connor, Owen A., Czuczman, Myron S., LaCasce, Ann S., Gerecitano, John F., Leonard, John P., Tulpule, Anil, Dunleavy, Kieron, Xiong, Hao, Chiu, Yi-Lin, Cui, Yue, Busman, Todd, Elmore, Steven W., Rosenberg, Saul H., Krivoshik, Andrew P., Enschede, Sari H., Humerickhouse, Rod A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025495/
https://ncbi.nlm.nih.gov/pubmed/21094089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(10)70261-8
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