Phase 1 Study of the Safety, Pharmacokinetics, and Antitumour Activity of the BCL2 Inhibitor Navitoclax in Combination With Rituximab in Patients With Relapsed or Refractory CD20+ Lymphoid Malignancies

The oral BCL2 inhibitor navitoclax has moderate single-agent efficacy in chronic lymphocytic leukaemia (CLL) and minor activity in lymphoma in Phase 1 trials. Navitoclax synergizes with rituximab in preclinical models of B-cell lymphoid cancers. We report the safety, pharmacokinetics, and clinical a...

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Udgivet i:Br J Haematol
Main Authors: Roberts, Andrew W., Advani, Ranjana H., Kahl, Brad, Persky, Daniel, Sweetenham, John W., Carney, Dennis A., Yang, Jianning, Busman, Todd B., Enschede, Sari H., Humerickhouse, Roderick A., Seymour, John F.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534314/
https://ncbi.nlm.nih.gov/pubmed/25942994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.13487
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