Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore

Kinetochores assemble on distinct ‘centrochromatin' containing the histone H3 variant CENP-A and interspersed nucleosomes dimethylated on H3K4 (H3K4me2). Little is known about how the chromatin environment at active centromeres governs centromeric structure and function. Here, we report that ce...

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Detalhes bibliográficos
Main Authors: Bergmann, Jan H, Rodríguez, Mariluz Gómez, Martins, Nuno M C, Kimura, Hiroshi, Kelly, David A, Masumoto, Hiroshi, Larionov, Vladimir, Jansen, Lars E T, Earnshaw, William C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025471/
https://ncbi.nlm.nih.gov/pubmed/21157429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.329
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