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Inhibition of Raf-1 Alters Multiple Downstream Pathways to Induce Pancreatic β-Cell Apoptosis
The serine threonine kinase Raf-1 plays a protective role in many cell types, but its function in pancreatic β-cells has not been elucidated. In the present study, we examined whether primary β-cells possess Raf-1 and tested the hypothesis that Raf-1 is critical for β-cell survival. Using reverse tr...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3025401/ https://ncbi.nlm.nih.gov/pubmed/18006502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M703612200 |
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